ABSTRACT
African Americans have faced health disparities in terms of access to health care and treatment of illnesses. The novel coronavirus disease 2019 pandemic exacerbates those disparities caused by limited access to medical care and healthy lifestyles, vulnerability to misleading information, and mistrust of the medical profession, all of which disproportionately affect the African American population in terms of infection and mortality. Conversational agents (CAs) are a technological intervention with the potential to narrow the disparities because they make health care more accessible, are effective in disseminating health information among a population with low health literacy, and can increase users' trust in health information. However, designing CAs for this population presents challenges with regard to embodying the African American culture into CAs and addressing privacy and security concerns. This commentary discusses some advantages and challenges of using CAs to help African Americans protect themselves against coronavirus disease 2019, and calls for more research in this area. © 2020 ACM.